[啮齿动物中DXPas34调控区的比较分析]

[Comparative analysis of the DXPas34 regulatory region in rodents].

作者信息

Malakhova A A, Piatkova M S, Elisafenko E A, Shevchenko A I, Kel' A É, Zakiian S M

出版信息

Genetika. 2010 Oct;46(10):1401-4.

Abstract

Mouse X chromosome inactivation center contains the DXPas34 minisatellite locus which plays an important role in expression regulation of the Tsix and Xist genes, involved into female dosage compensation. Comparative analysis of the DXPas34 locus from mouse, rat, and four common vole species revealed similar organization of this region in the form of tandem repeat blocks. A search for functionally important elements in this locus showed that all the species examined carried the conservative motif monomers, which could be involved in regulation of X inactivation.

摘要

小鼠X染色体失活中心包含DXPas34微卫星基因座，该基因座在Tsix和Xist基因的表达调控中起重要作用，参与雌性剂量补偿。对小鼠、大鼠和四种普通田鼠物种的DXPas34基因座进行比较分析，发现该区域具有相似的串联重复序列块形式的组织。对该基因座中功能重要元件的搜索表明，所有检测的物种都携带保守的基序单体，这些单体可能参与X染色体失活的调控。