Department of Dermatology and Venereology, University Hospital, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
J Dermatolog Treat. 2012 Jun;23(3):208-11. doi: 10.3109/09546634.2010.521811. Epub 2011 Jan 22.
The induction of psoriasis as a side effect of treatment with TNF-alpha inhibitors is one of a few rare complications of treatment, the pathogenic mechanism of which has not yet been completely clarified. The clinical presentation of these reactions may show the typical characteristics of psoriasis, palmoplantar pustulosis and psoriasiform exanthema; the individual variations of which may combine to give different presentations in individual patients. We present the case of a patient who, after administration of infliximab indicated for Crohn's disease, developed not only skin manifestations but also those of psoriatic arthritis.
作为 TNF-α 抑制剂治疗的副作用之一，诱导银屑病的发生是治疗的少数罕见并发症之一，其发病机制尚未完全阐明。这些反应的临床表现可能表现出典型的银屑病、掌跖脓疱病和银屑病样疹的特征；个体差异可能会在不同患者中组合出不同的表现。我们报告了一例患者，在给予英夫利昔单抗治疗克罗恩病后，不仅出现了皮肤表现，还出现了银屑病关节炎的表现。
