Dermatology Clinic, Numune Education and Research Hospital, Seyhan Practice Center, Adana, Turkey.
J Dermatolog Treat. 2012 Jun;23(3):177-83. doi: 10.3109/09546634.2010.519766. Epub 2011 Jan 22.
To compare the effectiveness of three different combinations of combined oral contraceptives (COCs) and anti-androgens in the treatment of hirsutism.
A total of 134 women with moderate and severe hirsutism were randomly assigned to three treatment regimens: Group I received 30 μg of ethinyl estradiol (EE)/3 mg of drospirenone (DRSP) plus 100 mg of cyproterone acetate (CPA) (n = 45); group II received 30 μg of EE/3 mg of DRSP plus 100 mg of spironolactone (n = 44); and group III received 35 μg of EE/2 mg of CPA plus 100 mg of CPA (n = 45), daily for 6 months. The decrease in the modified Ferriman-Gallwey hirsutism score (mFGS) was the main outcome measure.
The mean decrease in mFGS after 3 and 6 months of the treatment course was 26% and 49% in group I (both p < 0.01), 27% and 49% in group II (both p < 0.01), and 25% and 45% in group III (both p < 0.01), respectively, when compared with baseline. Although the mFGS was significantly decreased in all groups, there was no significant difference between groups.
CPA or DRSP containing COCs in combination with CPA or spironolactone have similar effects for the treatment of hirsutism.
比较三种不同联合口服避孕药（COC）和抗雄激素组合治疗高雄激素血症的疗效。
共 134 例中重度高雄激素血症患者随机分为三组治疗：组 I 给予炔雌醇 30μg/屈螺酮 3mg 加醋酸环丙孕酮 100mg（n=45）；组 II 给予炔雌醇 30μg/屈螺酮 3mg 加螺内酯 100mg（n=44）；组 III 给予炔雌醇 35μg/CPA 2mg 加醋酸环丙孕酮 100mg（n=45），每日 1 次，共 6 个月。主要疗效指标为改良 Ferriman-Gallwey 高雄激素血症评分（mFGS）的下降。
治疗 3 个月和 6 个月后，mFGS 平均下降 26%和 49%，组 I 与基线相比（均 p<0.01），27%和 49%，组 II （均 p<0.01），25%和 45%，组 III （均 p<0.01）。虽然 mFGS 各组均显著降低，但组间无显著差异。
含有 CPA 或 DRSP 的 COC 联合 CPA 或螺内酯治疗高雄激素血症的效果相似。
