University of Siena School of Medicine, Department of Mental Health and Neuroscience, Siena 53100, Italy.
Expert Opin Pharmacother. 2011 Feb;12(3):473-88. doi: 10.1517/14656566.2011.552429.
several medications are available for the treatment of different phases of bipolar disorder, yet many of the drugs that are currently approved carry a substantial burden of side effects or do not lead all treated patients to remission.
this paper comprises a review and commentary regarding the use of oral and intramuscular aripiprazole in the acute and maintenance phases of bipolar disorder. Basic principles in dosing, switching, management of side effects and co-administration of aripiprazole with other medications are provided. This paper presents practical strategies to translate the data from clinical research into clinical practice.
aripiprazole has proven to be an effective medication for the acute treatment of manic and mixed episodes, as well as for the prophylactic-maintenance phase of bipolar disorder in patients recovering from a manic/mixed episode. Choosing the appropriate dosing and tapering strategy, addressing the side effects, controlling withdrawal symptoms from previous medications and using adjunctive medications when necessary are key to successful treatment with aripiprazole.
有几种药物可用于治疗双相情感障碍的不同阶段，但目前批准的许多药物都有很大的副作用负担，或者不能使所有接受治疗的患者都缓解。
本文综述并评论了口服和肌肉注射阿立哌唑在双相情感障碍的急性期和维持期的应用。提供了剂量调整、转换、副作用管理以及阿立哌唑与其他药物联合应用的基本原则。本文提出了将临床研究数据转化为临床实践的实用策略。
阿立哌唑已被证明可有效治疗躁狂和混合发作，以及对从躁狂/混合发作中恢复的患者的双相情感障碍预防维持期。选择适当的剂量调整和逐渐减量策略、处理副作用、控制之前药物的戒断症状以及在必要时使用辅助药物是成功治疗阿立哌唑的关键。
