Skp2 和 Skp2B 联手对抗 Rb 和 p53。
Skp2 and Skp2B team up against Rb and p53.
机构信息
Mount Sinai School of Medicine, Tisch Cancer Institute, Division of Hematology/Oncology, One Gustave L, Levy Place, Box 1079, New York, New York 10029, USA.
出版信息
Cell Div. 2011 Jan 21;6(1):1. doi: 10.1186/1747-1028-6-1.
The Skp2 locus encodes two proteins, Skp2 and Skp2B. The role of Skp2 in the ubiquitin-dependent degradation of key regulators of the retinoblastoma protein pathway has been well established. More recent work from the McCormick's group suggested that Skp2 has an ubiquitin-independent function in the regulation of the p53 pathway. Adding to this observation, we reported that Skp2B also regulates the activity of p53 by degrading a distinct substrate, prohibitin. Since prohibitin has been implicated in the regulation of the Rb pathway, collectively, these observations suggest that Skp2 and Skp2B team up against p53 and Rb.
Skp2 基因座编码两种蛋白质，Skp2 和 Skp2B。Skp2 在视网膜母细胞瘤蛋白途径的关键调节因子的泛素依赖性降解中的作用已得到充分确立。McCormick 小组的最新研究表明，Skp2 在调节 p53 途径中具有泛素非依赖性功能。在此观察的基础上，我们报告 Skp2B 还通过降解另一种底物抑制素来调节 p53 的活性。由于抑制素与 Rb 途径的调节有关，这些观察结果表明 Skp2 和 Skp2B 联合起来对抗 p53 和 Rb。
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