Endothelin-1 and -3 induce the release of tissue-type plasminogen activator and von Willebrand factor from endothelial cells.
作者信息
Pruis J, Emeis J J
机构信息
Gaubius Institute TNO, Leiden, The Netherlands.
出版信息
Eur J Pharmacol. 1990 Oct 2;187(1):105-12. doi: 10.1016/0014-2999(90)90345-7.
PMID:2125563
Abstract
Stimulation of the isolated perfused rat hindleg vascular bed with various concentrations of endothelin-1 or endothelin-3 resulted in the acute release of tissue-type plasminogen activator (t-PA) and of von Willebrand factor (vWF). The release of both endothelial cell products required the presence of extracellular calcium; the release of vWF by endothelin was instantly inhibited by disodium EDTA. The calcium antagonists nifedipine, diltiazem and verapamil partially inhibited endothelin-induced t-PA release, but had no effect on endothelin-induced vWF release.
摘要
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