Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Leuk Res. 2011 May;35(5):685-8. doi: 10.1016/j.leukres.2011.01.002. Epub 2011 Jan 21.
Overexpression of the Wilms' tumor gene 1 (WT1) was observed in most leukemia cells. In addition to four major isoforms of WT1, an N-terminally truncated isoforms (sWT1) has been identified. We separately quantified the transcript levels of sWT1 and full-length WT1 (fWT1) in 237 patients with acute myeloid leukemia (AML). sWT1 expression was observed in 45 of 237 (19.0%) AML patients, particularly in acute promyelocytic leukemia (59.3%). Although sWT1 expression was not associated with other genetic mutations and prognosis, fWT1 expression level in sWT1-expressing AML was significantly higher than that in un-expressing AML. These results suggested the possible cooperation of sWT1 and fWT1 in the pathophysiology of AML, while further analysis is required.
Wilms' 肿瘤基因 1（WT1）的过表达在大多数白血病细胞中都观察到了。除了四个主要的 WT1 同工型外，还鉴定到了一个 N 端截断的同工型（sWT1）。我们分别在 237 例急性髓系白血病（AML）患者中定量检测了 sWT1 和全长 WT1（fWT1）的转录水平。在 237 例 AML 患者中观察到 45 例（19.0%）sWT1 表达，特别是在急性早幼粒细胞白血病（59.3%）中。尽管 sWT1 表达与其他基因突变和预后无关，但在表达 sWT1 的 AML 中 fWT1 的表达水平明显高于不表达 sWT1 的 AML。这些结果表明 sWT1 和 fWT1 可能在 AML 的病理生理学中存在合作，而需要进一步的分析。
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