Gambarana D, Tonani P, Bongiorno M, Focardi C, Biscaldi I, Cerbo R M
Clinica Pediatrica, Policlinico S. Matteo, Università di Pavia.
Medicina (Firenze). 1990 Apr-Jun;10(2):152-4.
Gonadal impairment has been observed in patients who underwent bone marrow transplantation with TBI-containing cytoreductive regimen. In order to study the effects of radiations on the pituitary and gonadal hormones 12-18 months after transplantation sexual development and plasma levels of gonadotropins, estradiol, and testosterone were evaluated in 9 patients (4 boys and 5 girls, age range 11-20 years). The preliminary results of this study show that TBI produces in both sexes a gonadal impairment, as shown by the high plasma levels of gonadotropins. Nevertheless, the gonadal damage seems to be more important in girls and we suppose a greater sensitivity to radiation injury of the ovary than of the testis.
接受含全身照射（TBI）的骨髓移植预处理方案的患者出现了性腺功能损害。为了研究移植后12 - 18个月辐射对垂体和性腺激素的影响，对9例患者（4例男孩和5例女孩，年龄范围11 - 20岁）的性发育以及促性腺激素、雌二醇和睾酮的血浆水平进行了评估。本研究的初步结果表明，TBI在男女两性中均导致性腺功能损害，促性腺激素的高血浆水平表明了这一点。然而，性腺损害在女孩中似乎更为严重，我们推测卵巢对辐射损伤的敏感性高于睾丸。
