Bregman J D, Leckman J F, Ort S I
Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06510.
Yale J Biol Med. 1990 Jul-Aug;63(4):293-9.
Twelve males with fragile-X syndrome between the ages of three and 28 years underwent assessment of thyroid function. All 12 subjects demonstrated normal baseline values for thyroid stimulating hormone (TSH), thyroxine, thyroid binding globulin (TBG), and estimated free thyroxine (EFT). Relative to a control group reported in the literature, however, the fragile-X subjects exhibited a blunted TSH response to thyrotropin releasing hormone (TRH). This finding suggests the presence of subtle dysfunction within the hypothalamic-pituitary-thyroid axis. Elevated baseline prolactin levels were also observed among the fragile-X subjects. These results support previous reports of hypothalamic-pituitary abnormalities among fragile-X syndrome males.
12名年龄在3岁至28岁之间的脆性X综合征男性接受了甲状腺功能评估。所有12名受试者的促甲状腺激素（TSH）、甲状腺素、甲状腺结合球蛋白（TBG）和估计游离甲状腺素（EFT）的基线值均正常。然而，与文献中报道的对照组相比，脆性X受试者对促甲状腺激素释放激素（TRH）的TSH反应迟钝。这一发现提示下丘脑-垂体-甲状腺轴存在细微功能障碍。在脆性X受试者中还观察到基线催乳素水平升高。这些结果支持了先前关于脆性X综合征男性下丘脑-垂体异常的报道。
