Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Nat Rev Cancer. 2011 Feb;11(2):123-34. doi: 10.1038/nrc3004.
Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.
大量实验证据表明，血小板支持肿瘤转移。血小板的激活和凝血系统在癌症的进展中起着关键作用。在循环系统中，血小板保护肿瘤细胞免受免疫清除，并促进它们在内皮细胞上的停滞，从而支持继发性病变的建立。血小板对肿瘤细胞存活和扩散的这些贡献表明血小板是一种新的治疗途径。
