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A combination of 1α,25-dihydroxyvitamin D3, a plant-derived antioxidant and an inhibitor of the Cot1/Tlp2 oncogene as molecularly targeted weapons in the hematologist's battle against acute myeloid leukemias.

作者信息

Hughes Philip J, Brown Geoffrey

出版信息

Cell Cycle. 2010 Dec 1;9(23):4612-3. doi: 10.4161/cc.9.23.13932.

DOI:10.4161/cc.9.23.13932
PMID:21260950
Abstract
摘要

相似文献

1
A combination of 1α,25-dihydroxyvitamin D3, a plant-derived antioxidant and an inhibitor of the Cot1/Tlp2 oncogene as molecularly targeted weapons in the hematologist's battle against acute myeloid leukemias.1α,25 - 二羟基维生素D3、一种植物源抗氧化剂以及Cot1/Tlp2癌基因抑制剂的组合，作为血液科医生对抗急性髓系白血病的分子靶向武器。
Cell Cycle. 2010 Dec 1;9(23):4612-3. doi: 10.4161/cc.9.23.13932.
2
Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).抑制 AML 细胞中的 Cot1/Tlp2 癌基因可减少 ERK5 的激活并上调 p27Kip1，同时增强水飞蓟宾和 1,25-二羟维生素 D(3)诱导的分化和细胞周期阻滞。
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3
Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells.癌蛋白 Cot1 抑制 Ras1/2 和 1,25-二羟维生素 D3 诱导的人急性髓系白血病细胞分化的激酶抑制剂。
J Cell Physiol. 2011 May;226(5):1232-40. doi: 10.1002/jcp.22449.
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J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):395-8. doi: 10.1016/j.jsbmb.2010.03.016. Epub 2010 Mar 19.
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Superior activity of the combination of histone deacetylase inhibitor LAQ824 and the FLT-3 kinase inhibitor PKC412 against human acute myelogenous leukemia cells with mutant FLT-3.组蛋白脱乙酰酶抑制剂LAQ824与FLT-3激酶抑制剂PKC412联合使用对携带FLT-3突变的人急性髓性白血病细胞具有更强的活性。
Clin Cancer Res. 2004 Aug 1;10(15):4991-7. doi: 10.1158/1078-0432.CCR-04-0210.
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Carnosic acid potentiates the antioxidant and prodifferentiation effects of 1alpha,25-dihydroxyvitamin D3 in leukemia cells but does not promote elevation of basal levels of intracellular calcium.鼠尾草酸可增强1α,25-二羟基维生素D3在白血病细胞中的抗氧化和促分化作用，但不会促使细胞内钙的基础水平升高。
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Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.波洛样激酶强效选择性抑制剂沃拉泽替布在急性髓系白血病临床前模型中的疗效及作用机制
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Control of proliferating potential of myeloid leukemia cells during long-term treatment with vitamin D3 analogues and other differentiation inducers in combination with antileukemic drugs: in vitro and in vivo studies.维生素D3类似物及其他分化诱导剂与抗白血病药物联合长期治疗期间对髓系白血病细胞增殖潜能的控制：体外和体内研究
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Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.17-烯丙基氨基-去甲氧基格尔德霉素与FLT-3激酶抑制剂PKC412联合治疗对携带FLT-3突变的人急性髓性白血病细胞具有高效作用。
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Curr Opin Hematol. 2005 Jan;12(1):7-13. doi: 10.1097/01.moh.0000147891.06584.d7.