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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Svejdová M, Rektor I, Silva-Barrat C, Menini C

Department de Neurophysiologie Appliquée, CNRS, Gif-sur-Yvette, France.

Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(6):961-6. doi: 10.1016/0278-5846(90)90081-q.

The influence of 7-methoxytacrine (7-MEOTA) on the non epileptic myoclonus of the Papio papio baboon was studied in 5 animals. 2. This type of myoclonus is thought to depend on a cholinergic system dysfunction since it can be induced by atropine and blocked by physostigmine. 3. 7-MEOTA, a tacrine derivative, is believed to display a conspicuous anticholinesterase activity but, surprisingly, it here potentiated the non epileptic myoclonus occuring either spontaneously or induced by atropine. 4. In baboons not spontaneously presenting the non epileptic myoclonus, 7-MEOTA induced the myoclonus in a fashion similar to atropine; such a myoclonus was blocked by physostigmine. 5. These data indicate a possible antagonist action of tacrine on the muscarinic acetylcholine receptor. From these data, it is suggested that caution is necessary when introducing a tacrine derivative in clinical practice.

在5只动物身上研究了7-甲氧基他克林（7-MEOTA）对狒狒非癫痫性肌阵挛的影响。2. 这种类型的肌阵挛被认为依赖于胆碱能系统功能障碍，因为它可由阿托品诱发并被毒扁豆碱阻断。3. 7-MEOTA是一种他克林衍生物，据信具有显著的抗胆碱酯酶活性，但令人惊讶的是，它在此增强了自发出现或由阿托品诱发的非癫痫性肌阵挛。4. 在未自发出现非癫痫性肌阵挛的狒狒中，7-MEOTA以类似于阿托品的方式诱发肌阵挛；这种肌阵挛被毒扁豆碱阻断。5. 这些数据表明他克林对毒蕈碱型乙酰胆碱受体可能具有拮抗作用。根据这些数据，建议在临床实践中引入他克林衍生物时要谨慎。

Svejdová M, Rektor I, Silva-Barrat C, Menini C

Department de Neurophysiologie Appliquée, CNRS, Gif-sur-Yvette, France.

Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(6):961-6. doi: 10.1016/0278-5846(90)90081-q.

The influence of 7-methoxytacrine (7-MEOTA) on the non epileptic myoclonus of the Papio papio baboon was studied in 5 animals. 2. This type of myoclonus is thought to depend on a cholinergic system dysfunction since it can be induced by atropine and blocked by physostigmine. 3. 7-MEOTA, a tacrine derivative, is believed to display a conspicuous anticholinesterase activity but, surprisingly, it here potentiated the non epileptic myoclonus occuring either spontaneously or induced by atropine. 4. In baboons not spontaneously presenting the non epileptic myoclonus, 7-MEOTA induced the myoclonus in a fashion similar to atropine; such a myoclonus was blocked by physostigmine. 5. These data indicate a possible antagonist action of tacrine on the muscarinic acetylcholine receptor. From these data, it is suggested that caution is necessary when introducing a tacrine derivative in clinical practice.

在5只动物身上研究了7-甲氧基他克林（7-MEOTA）对狒狒非癫痫性肌阵挛的影响。2. 这种类型的肌阵挛被认为依赖于胆碱能系统功能障碍，因为它可由阿托品诱发并被毒扁豆碱阻断。3. 7-MEOTA是一种他克林衍生物，据信具有显著的抗胆碱酯酶活性，但令人惊讶的是，它在此增强了自发出现或由阿托品诱发的非癫痫性肌阵挛。4. 在未自发出现非癫痫性肌阵挛的狒狒中，7-MEOTA以类似于阿托品的方式诱发肌阵挛；这种肌阵挛被毒扁豆碱阻断。5. 这些数据表明他克林对毒蕈碱型乙酰胆碱受体可能具有拮抗作用。根据这些数据，建议在临床实践中引入他克林衍生物时要谨慎。