Department of Cytobiochemistry, Medical University of Lublin, Lublin, Poland.
Cancer Invest. 2011 Feb;29(2):137-44. doi: 10.3109/07357907.2010.543213.
TGFβ signaling cascade plays a vital role in neoplastic transformation, but the function of betaglycan, which is a TGFβ accessory receptor, is still unknown in particular cancer. Evaluation of betaglycan expression both at mRNA (real-time PCR) and protein (ELISA) level in the context of TGFβ canonical signaling components, i.e., TGFβ1, TGFβ2, and TGFβRII, in endometrial carcinomas was performed. Betaglycan mRNA expression level was significantly (p < .001) downregulated with simultaneous betaglycan protein level upregulation in cancer samples. Obtained results suggest that endometrial cancer is associated with disruption of accessory receptor betaglycan expression, what may alter TGFβ2-induced signaling.
TGFβ 信号级联在肿瘤转化中起着至关重要的作用，但β糖蛋白作为 TGFβ 辅助受体的功能在特定癌症中仍不清楚。评估子宫内膜癌中 TGFβ 经典信号成分（TGFβ1、TGFβ2 和 TGFβRII）的β糖蛋白表达在 mRNA（实时 PCR）和蛋白（ELISA）水平上的情况。在癌症样本中，β糖蛋白 mRNA 表达水平显著下调（p<0.001），同时β糖蛋白蛋白水平上调。研究结果表明，子宫内膜癌与辅助受体β糖蛋白表达的破坏有关，这可能改变 TGFβ2 诱导的信号。
