自愿转轮运动可抵抗无法逃避的应激诱导的吗啡条件性位置偏爱增强。
Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference.
机构信息
University of Colorado-Boulder, Department of Psychology and Neuroscience, Muenzinger Building, UCB 345, Boulder, CO 80309, USA.
出版信息
Behav Brain Res. 2011 Jun 1;219(2):378-81. doi: 10.1016/j.bbr.2011.01.030. Epub 2011 Jan 22.
Abstract
In rodents, exposure to acute inescapable, but not escapable, stress potentiates morphine conditioned place preference (CPP), an effect that is dependent upon hyperactivation of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN). Six weeks of voluntary wheel running constrains activation of DRN 5-HT neurons during exposure to inescapable stress. Six weeks of voluntary wheel running before inescapable stress blocked stress-induced potentiation of morphine CPP.
摘要
在啮齿类动物中，急性不可逃避但可逃避的应激暴露会增强吗啡条件性位置偏爱（CPP），这种效应依赖于中缝背核（DRN）5-羟色胺（5-HT）神经元的过度激活。6 周的自愿轮跑会限制在不可逃避的应激暴露期间 DRN 5-HT 神经元的激活。在不可逃避的应激之前进行 6 周的自愿轮跑会阻止应激诱导的吗啡 CPP 的增强。
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