自愿转轮运动可抵抗无法逃避的应激诱导的吗啡条件性位置偏爱增强。
Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference.
机构信息
University of Colorado-Boulder, Department of Psychology and Neuroscience, Muenzinger Building, UCB 345, Boulder, CO 80309, USA.
出版信息
Behav Brain Res. 2011 Jun 1;219(2):378-81. doi: 10.1016/j.bbr.2011.01.030. Epub 2011 Jan 22.
Abstract
In rodents, exposure to acute inescapable, but not escapable, stress potentiates morphine conditioned place preference (CPP), an effect that is dependent upon hyperactivation of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN). Six weeks of voluntary wheel running constrains activation of DRN 5-HT neurons during exposure to inescapable stress. Six weeks of voluntary wheel running before inescapable stress blocked stress-induced potentiation of morphine CPP.
摘要
在啮齿类动物中，急性不可逃避但可逃避的应激暴露会增强吗啡条件性位置偏爱（CPP），这种效应依赖于中缝背核（DRN）5-羟色胺（5-HT）神经元的过度激活。6 周的自愿轮跑会限制在不可逃避的应激暴露期间 DRN 5-HT 神经元的激活。在不可逃避的应激之前进行 6 周的自愿轮跑会阻止应激诱导的吗啡 CPP 的增强。
相似文献
1
Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference.
Behav Brain Res. 2011 Jun 1;219(2):378-81. doi: 10.1016/j.bbr.2011.01.030. Epub 2011 Jan 22.
2
Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats.
Psychopharmacology (Berl). 2004 Jan;171(2):191-8. doi: 10.1007/s00213-003-1572-1. Epub 2003 Sep 10.
3
CRF-5-HT interactions in the dorsal raphe nucleus and motivation for stress-induced opioid reinstatement.
Psychopharmacology (Berl). 2021 Jan;238(1):29-40. doi: 10.1007/s00213-020-05652-3. Epub 2020 Nov 24.
4
Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus.
Neuroscience. 2004;126(3):705-15. doi: 10.1016/j.neuroscience.2004.04.025.
5
Morphine history sensitizes postsynaptic GABA receptors on dorsal raphe serotonin neurons in a stress-induced relapse model in rats.
Psychoneuroendocrinology. 2012 Jun;37(6):859-70. doi: 10.1016/j.psyneuen.2011.10.002. Epub 2011 Nov 1.
6
Uncontrollable stress potentiates morphine's rewarding properties.
Pharmacol Biochem Behav. 1998 Jul;60(3):655-64. doi: 10.1016/s0091-3057(98)00027-6.
7
Role of GABAA receptors in dorsal raphe nucleus in stress-induced reinstatement of morphine-conditioned place preference in rats.
Psychopharmacology (Berl). 2013 Dec;230(4):537-45. doi: 10.1007/s00213-013-3182-x. Epub 2013 Jun 28.
8
Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress-induced potentiation of morphine conditioned place preference.
Eur J Neurosci. 2012 Jan;35(1):160-5. doi: 10.1111/j.1460-9568.2011.07929.x. Epub 2011 Nov 25.
9
Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons.
J Neurosci. 2003 Apr 1;23(7):2889-98. doi: 10.1523/JNEUROSCI.23-07-02889.2003.
10
Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus.
Behav Brain Res. 1999 Mar;99(2):153-67. doi: 10.1016/s0166-4328(98)00101-6.
引用本文的文献
1
Effect of Voluntary Wheel-Running Exercise on the Endocrine and Inflammatory Response to Social Stress: Conditioned Rewarding Effects of Cocaine.
Biomedicines. 2022 Sep 23;10(10):2373. doi: 10.3390/biomedicines10102373.
2
Sex differences in resilience: Experiential factors and their mechanisms.
Eur J Neurosci. 2020 Jul;52(1):2530-2547. doi: 10.1111/ejn.14639. Epub 2019 Dec 20.
3
Behavioral and Biochemical Impact of Chronic Unpredictable Mild Stress on the Acquisition of Nicotine Conditioned Place Preference in Rats.
Mol Neurobiol. 2018 Apr;55(4):3270-3289. doi: 10.1007/s12035-017-0585-4. Epub 2017 May 8.
4
Parameters for abolishing conditioned place preference for cocaine from running and environmental enrichment in male C57BL/6J mice.
Behav Brain Res. 2016 Oct 1;312:366-73. doi: 10.1016/j.bbr.2016.06.049. Epub 2016 Jun 27.
5
Effect of Opioid on Adult Hippocampal Neurogenesis.
ScientificWorldJournal. 2016;2016:2601264. doi: 10.1155/2016/2601264. Epub 2016 Apr 5.
6
Running Reduces Uncontrollable Stress-Evoked Serotonin and Potentiates Stress-Evoked Dopamine Concentrations in the Rat Dorsal Striatum.
PLoS One. 2015 Nov 10;10(11):e0141898. doi: 10.1371/journal.pone.0141898. eCollection 2015.
7
Wheel running alters patterns of uncontrollable stress-induced cfos mRNA expression in rat dorsal striatum direct and indirect pathways: A possible role for plasticity in adenosine receptors.
Behav Brain Res. 2014 Oct 1;272:252-63. doi: 10.1016/j.bbr.2014.07.006. Epub 2014 Jul 11.
8
Effect of baclofen on morphine-induced conditioned place preference, extinction, and stress-induced reinstatement in chronically stressed mice.
Psychopharmacology (Berl). 2014 Jan;231(1):27-36. doi: 10.1007/s00213-013-3204-8. Epub 2013 Jul 28.
9
Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis.
Neurosci Biobehav Rev. 2013 Sep;37(8):1622-44. doi: 10.1016/j.neubiorev.2013.06.011. Epub 2013 Jun 24.
10
Stress, κ manipulations, and aversive effects of ethanol in adolescent and adult male rats.
Neuroscience. 2013 Sep 26;249:214-22. doi: 10.1016/j.neuroscience.2012.12.028. Epub 2012 Dec 29.
本文引用的文献
1
A Pilot Study of Aerobic Exercise as an Adjunctive Treatment for Drug Dependence.
Ment Health Phys Act. 2010 Jun 1;3(1):27-34. doi: 10.1016/j.mhpa.2010.03.001.
2
Exercise treatment for drug abuse--a Danish pilot study.
Scand J Public Health. 2010 Aug;38(6):664-9. doi: 10.1177/1403494810371249. Epub 2010 Jun 7.
3
Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.
Ann N Y Acad Sci. 2010 Feb;1187:184-207. doi: 10.1111/j.1749-6632.2009.05275.x.
4
Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model.
Behav Neurosci. 2009 Apr;123(2):382-96. doi: 10.1037/a0014592.
5
Stress, alcohol and drug interaction: an update of human research.
Addict Biol. 2009 Jan;14(1):43-64. doi: 10.1111/j.1369-1600.2008.00131.x. Epub 2008 Oct 9.
6
The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration.
Behav Brain Res. 2008 Nov 3;193(1):87-93. doi: 10.1016/j.bbr.2008.04.024. Epub 2008 May 4.
7
The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress.
Neuropsychopharmacology. 2009 Mar;34(4):834-43. doi: 10.1038/npp.2008.34. Epub 2008 Mar 26.
8
Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear.
Neuroscience. 2007 Jun 8;146(4):1495-503. doi: 10.1016/j.neuroscience.2007.03.042. Epub 2007 May 2.
9
Chronic and voluntary exercise enhances learning of conditioned place preference to morphine in rats.
Pharmacol Biochem Behav. 2007 Apr;86(4):607-15. doi: 10.1016/j.pbb.2007.02.002. Epub 2007 Feb 9.
10
Drug addiction: pathways to the disease and pathophysiological perspectives.
Eur Neuropsychopharmacol. 2007 May-Jun;17(6-7):377-93. doi: 10.1016/j.euroneuro.2006.10.006. Epub 2006 Dec 12.
Zotero 插件