Pharmacy Department, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
Microbes Infect. 2011 May;13(5):419-25. doi: 10.1016/j.micinf.2011.01.004. Epub 2011 Jan 22.
Neurological complications associated with HIV-1 are being recognized as a common disorder in AIDS patients, especially patients with HIV-associated dementia (HAD). However, our knowledge of the complicated pathogenesis and clinical symptoms of HAD is limited by an incomplete understanding of the biology of HIV-1 in the nervous system. Therefore, this review focuses on the pathogenesis of HAD in the context of novel highly active antiretroviral therapy (HARRT) regimens.
与 HIV-1 相关的神经系统并发症在 AIDS 患者中被认为是一种常见疾病，尤其是 HIV 相关痴呆（HAD）患者。然而，由于我们对 HIV-1 在神经系统中的生物学特性认识不足，因此 HAD 的复杂发病机制和临床表现仍知之甚少。因此，本文主要探讨了新型高效抗逆转录病毒疗法（HARRT）方案背景下 HAD 的发病机制。
