可控爆破：Smurf1 通过基质转换调节神经元极性。
Controlled demolition: Smurf1 regulates neuronal polarity by substrate switching.
机构信息
Axonal Growth and Regeneration Group, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany.
出版信息
Neuron. 2011 Jan 27;69(2):183-5. doi: 10.1016/j.neuron.2011.01.007.
PMID:21262456
Abstract
During axon specification, growth promoting proteins localize selectively to the growing axon. In this issue of Neuron, Cheng et al. report how selective protein degradation, controlled by a substrate switch of the ubiquitin ligase Smurf1, specifies Par6 and RhoA localization and thereby regulates neuronal polarity.
摘要
在轴突特化过程中，生长促进蛋白选择性地定位于生长的轴突。在本期《神经元》中，Cheng 等人报告了泛素连接酶 Smurf1 通过底物转换进行的选择性蛋白降解如何特异地定位 Par6 和 RhoA，并由此调节神经元极性。
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