Wiggin Giselle R, Fawcett James P, Pawson Tony
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
Dev Cell. 2005 Jun;8(6):803-16. doi: 10.1016/j.devcel.2005.05.007.
The neuron is a prime example of a highly polarized cell. It is becoming clear that conserved protein complexes, which have been shown to regulate polarity in such diverse systems as the C. elegans zygote and mammalian epithelia, are also required for neuronal polarization. This review considers the role of these polarity proteins in axon specification and synaptogenesis.
神经元是高度极化细胞的典型例子。越来越清楚的是，在秀丽隐杆线虫受精卵和哺乳动物上皮细胞等多种系统中已被证明可调节极性的保守蛋白复合物，对于神经元极化也是必需的。本文综述了这些极性蛋白在轴突特化和突触形成中的作用。
