Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Neuron. 2011 Jan 27;69(2):387-96. doi: 10.1016/j.neuron.2010.12.027.
Normal brain function requires the dynamic interaction of functionally specialized but widely distributed cortical regions. Long-range synchronization of oscillatory signals has been suggested to mediate these interactions within large-scale cortical networks, but direct evidence is sparse. Here we show that oscillatory synchronization is organized in such large-scale networks. We implemented an analysis approach that allows for imaging synchronized cortical networks and applied this technique to EEG recordings in humans. We identified two networks: beta-band synchronization (20 Hz) in a fronto-parieto-occipital network and gamma-band synchronization (80 Hz) in a centro-temporal network. Strong perceptual correlates support their functional relevance: the strength of synchronization within these networks predicted the subjects' perception of an ambiguous audiovisual stimulus as well as the integration of auditory and visual information. Our results provide evidence that oscillatory neuronal synchronization mediates neuronal communication within frequency-specific, large-scale cortical networks.
正常的大脑功能需要功能专门化但广泛分布的皮质区域之间的动态相互作用。长程振荡信号的同步被认为介导了这些大尺度皮质网络中的相互作用，但直接证据很少。在这里，我们展示了振荡同步在这些大尺度网络中是有组织的。我们实现了一种可以对同步皮质网络进行成像的分析方法，并将该技术应用于人类的 EEG 记录。我们确定了两个网络：额顶枕颞网络中的β波段同步（20 Hz）和中央颞网络中的γ波段同步（80 Hz）。强烈的知觉相关性支持它们的功能相关性：这些网络内的同步强度预测了受试者对一个模棱两可的视听刺激的感知，以及听觉和视觉信息的整合。我们的结果提供了证据，表明振荡神经元同步在特定频率的大尺度皮质网络中介导神经元通讯。
