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Successful treatment of refractory acute GVHD complicated by severe intestinal transplant-associated thrombotic microangiopathy using recombinant thrombomodulin.

作者信息

Inoue Yasuyuki, Kosugi Shigeki, Miura Ikuo, Hatta Yoshihiro, Takeuchi Jin

出版信息

Thromb Res. 2011 Jun;127(6):603-4. doi: 10.1016/j.thromres.2010.12.023. Epub 2011 Jan 22.

DOI:10.1016/j.thromres.2010.12.023
PMID:21262525
Abstract
摘要

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Thrombomodulin in disseminated intravascular coagulation and other critical conditions-a multi-faceted anticoagulant protein with therapeutic potential.弥散性血管内凝血及其他危急情况下的血栓调节蛋白——一种具有治疗潜力的多功能抗凝蛋白。
Crit Care. 2019 Aug 15;23(1):280. doi: 10.1186/s13054-019-2552-0.
2
Hematopoietic stem cell transplant-associated thrombotic microangiopathy: current paradigm and novel therapies.造血干细胞移植相关性血栓性微血管病：现有模式与新型疗法。
Bone Marrow Transplant. 2018 Feb;53(2):129-137. doi: 10.1038/bmt.2017.207. Epub 2017 Oct 2.
3
A donor thrombomodulin gene variation predicts graft-versus-host disease development and mortality after bone marrow transplantation.
供体血栓调节蛋白基因变异可预测骨髓移植后移植物抗宿主病的发生及死亡率。
Int J Hematol. 2015 Oct;102(4):460-70. doi: 10.1007/s12185-015-1852-7. Epub 2015 Aug 6.
4
Innate immune activation by tissue injury and cell death in the setting of hematopoietic stem cell transplantation.造血干细胞移植背景下组织损伤和细胞死亡引起的固有免疫激活
Front Immunol. 2015 Mar 16;6:101. doi: 10.3389/fimmu.2015.00101. eCollection 2015.
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Early coagulation disorder after allogeneic stem cell transplantation is a strong prognostic factor for transplantation-related mortality, and intervention with recombinant human thrombomodulin improves the outcome: a single-center experience.异基因干细胞移植后早期凝血障碍是与移植相关死亡率的一个强有力的预后因素，用重组人血栓调节蛋白进行干预可改善结局：一项单中心经验。
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Pathogenesis of graft-versus-host disease: innate immunity amplifying acute alloimmune responses.移植物抗宿主病的发病机制：固有免疫放大急性同种免疫反应。
Int J Hematol. 2013 Sep;98(3):293-9. doi: 10.1007/s12185-013-1421-x. Epub 2013 Aug 28.