Metabolic Unit, Kaplan Medical Center, Rehovot, Faculty of Medicine, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Diab Vasc Dis Res. 2011 Jan;8(1):43-6. doi: 10.1177/1479164110396919.
Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression test in apparently healthy individuals with prehypertension (n=126) and to elucidate the relationship between insulin action and CVD risk.We found a marked heterogeneity in insulin sensitivity in the prehypertension group, and when we divided the population into insulin-sensitive, insulin-resistant and intermediate groups, there were significant (p<0.01) increases in plasma glucose and triglyceride concentrations and decreases in high-density lipoprotein cholesterol concentrations with progressive degrees of insulin resistance. These data show that at least one-third of patients with prehypertension are insulin resistant, display the accompanying metabolic abnormalities, and merit enhanced surveillance and intensive efforts at therapeutic intervention to prevent CVD.
高血压前期被认为与心血管疾病（CVD）风险增加有关，一些数据表明该人群中胰岛素抵抗较为常见。本研究的目的是通过测定胰岛素抑制试验中的稳态血糖（SSPG）浓度来量化胰岛素作用，以评估在血压正常高值人群（n=126）中胰岛素作用与 CVD 风险的关系。我们发现高血压前期人群的胰岛素敏感性存在明显异质性，当我们将人群分为胰岛素敏感、胰岛素抵抗和中间组时，随着胰岛素抵抗程度的增加，血糖和甘油三酯浓度显著升高（p<0.01），而高密度脂蛋白胆固醇浓度降低。这些数据表明，至少三分之一的高血压前期患者存在胰岛素抵抗，表现出相应的代谢异常，值得加强监测和积极的治疗干预，以预防 CVD。
