Department of Diagnostic Imaging, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Cancer J. 2011 Jan-Feb;17(1):38-48. doi: 10.1097/PPO.0b013e31820a0948.
Nonsurgical management of early primary lung cancer has grown tremendously in recent years, and today, available options extend far beyond that of conventional radiation therapy (CRT) to include minimally invasive image-guided delivery of thermal energies, specifically radiofrequency ablation, microwave ablation, and cryoablation, and more conformal stereotactic body radiation therapy. Because the tumor is never resected with these nonoperative interventions, histopathological evaluation of tumor margins for the presence of residual tumor is impossible, and as such, tumor response after each of these therapies is largely based on imaging. To date, computerized tomography and computerized tomography-positron emission tomography remain the most readily available modalities for assessment of therapeutic efficacy, and to this end as detailed within this article, strict imaging survey and familiarity with the expected imaging characteristics of the treated tumor will aid in recognition of unexpected findings, specifically those of incomplete therapy and/or tumor recurrence.
近年来,早期原发性肺癌的非手术治疗得到了极大的发展,目前的治疗选择远远超出了传统的放射治疗(CRT),包括微创图像引导的热能传递,特别是射频消融、微波消融和冷冻消融,以及更适形的立体定向体部放射治疗。由于这些非手术干预措施从未切除肿瘤,因此不可能对肿瘤边缘的组织病理学评估是否存在残留肿瘤,因此,这些治疗方法后的肿瘤反应在很大程度上取决于影像学。迄今为止,计算机断层扫描和计算机断层扫描正电子发射断层扫描仍然是评估治疗效果最方便的方法,为此,正如本文所详述的,严格的影像学检查和熟悉治疗肿瘤的预期影像学特征将有助于识别意外发现,特别是那些治疗不彻底和/或肿瘤复发的情况。
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