Department of Bioimaging and Radiological Sciences, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.
Eur Radiol. 2012 Mar;22(3):588-606. doi: 10.1007/s00330-011-2299-8. Epub 2011 Oct 4.
To review the role of imaging in the diagnosis of recurrent disease in previously treated non-small cell lung cancer (NSCLC) and discuss the imaging pitfalls.
A comprehensive review of published literature on CT and PET imaging of NSCLC recurrence was performed. Diagnostic and prognostic values are discussed. Representative imaging examples are illustrated.
Up to 30% of NSCLC recurrences present as loco-regional, involving treated hemithorax and ipsilateral lymph nodes, while 70% present as metachronous distant metastases. CT and PET-CT play an important role in the early detection of recurrence; indications for imaging vary depending on pathological features.
Imaging plays a central role in the identification of recurrence and may predict prognosis.
Lung cancer recurs after surgery in 30% to 75% of patients. CT and PET-CT are crucial in identification of loco-regional recurrence. Knowledge of potential pitfalls is essential, especially for parenchymal or nodal recurrence. CT can diagnose metastases but further examinations (PET-CT, MRI) are often needed. Morphological and functional imaging criteria may help in predicting recurrence.
回顾影像学在诊断经治非小细胞肺癌（NSCLC）复发中的作用，并讨论影像学中的陷阱。
对 NSCLC 复发的 CT 和 PET 影像学的已发表文献进行了全面复习。讨论了诊断和预后价值。列举了有代表性的影像学实例。
多达 30%的 NSCLC 复发表现为局部区域复发，累及治疗过的半胸和同侧淋巴结，而 70%表现为异时性远处转移。CT 和 PET-CT 在早期检测复发中发挥重要作用；影像学的适应证取决于病理特征。
影像学在识别复发方面起着核心作用，并可能预测预后。
手术后 30%至 75%的肺癌患者会复发。CT 和 PET-CT 对局部区域复发的识别至关重要。了解潜在的陷阱至关重要，特别是对于实质或淋巴结复发。CT 可诊断转移，但通常需要进一步检查（PET-CT、MRI）。形态和功能影像学标准有助于预测复发。
