Blais D, Pharm B, Pharm L P
Can Fam Physician. 1987 Nov;33:2545-8.
The extensive use of benzodiazepines in treating anxiety and insomnia makes clinicians ask themselves about the risk of addiction relating to these drugs.(1-3) Indeed, it is estimated that in Canada, the United-States, and Western Europe, between 10% and 20% of persons use tranquilizers or hypnotics (mostly benzodiazepines) during a one-year period. Of these persons 70% are 50 years of age or more. It has been noted that 15% of those persons have been using these drugs for more than 12 months.(4, 5) In 1980, Tyrer reported that 50% of the patients who receive a prescription for benzodiazepines renew that prescription without consulting their physician.(6) In this article, the authors briefly review the dependency, risk factors and clinical signs resulting from withdrawal of these drugs. They also define a rational therapeutic approach to discontinuing their use.
苯二氮䓬类药物在治疗焦虑和失眠方面的广泛应用，促使临床医生思考这些药物的成瘾风险。（1 - 3）事实上，据估计，在加拿大、美国和西欧，每年有10%至20%的人使用镇静剂或催眠药（主要是苯二氮䓬类药物）。在这些人中，70%的年龄在50岁及以上。据观察，其中15%的人使用这些药物的时间超过了12个月。（4, 5）1980年，泰勒报告称，50%接受苯二氮䓬类药物处方的患者在未咨询医生的情况下就续签了处方。（6）在本文中，作者简要回顾了这些药物停药后产生的依赖性、风险因素和临床症状。他们还确定了停用这些药物的合理治疗方法。
