Louis Sherif F, Zahradka Peter
Canadian Centre for Agri-Food Research in Health and Medicine (CCARM), St Boniface Hospital Research Centre; and Department of Physiology, University of Manitoba, Winnipeg, Manitoba.
Exp Clin Cardiol. 2010 Winter;15(4):e75-85.
Over the past decade, extensive research has focused on identifying the molecular mechanisms and signal transduction pathways involved in the modulation of vascular smooth muscle cell phenotypes. In the present review, the characteristics of vascular smooth muscle cell (VSMC) phenotypes as they relate to cell migration are discussed based on insights from recent molecular findings. A central theme is the mechanisms involved in nonpathogenic VSMC migration during tissue repair versus VSMC invasion that leads to the development of vascular diseases. The issue of how various factors that are released locally following tissue injury influence cell migration will also be addressed.
在过去十年中，广泛的研究集中在确定参与调节血管平滑肌细胞表型的分子机制和信号转导途径。在本综述中，基于最近分子研究的见解，讨论了与细胞迁移相关的血管平滑肌细胞（VSMC）表型的特征。一个核心主题是组织修复过程中无致病性VSMC迁移与导致血管疾病发展的VSMC侵袭所涉及的机制。还将探讨组织损伤后局部释放的各种因素如何影响细胞迁移的问题。
