环氧化酶-2特异性抑制对兔胫骨直接骨折愈合的影响。
The effect of Cox-2 specific inhibition on direct fracture healing in the rabbit tibia.
作者信息
Hak David J, Schulz Kurt S, Khoie Behrang, Hazelwood Scott J
机构信息
Denver Health/University of Colorado, 777 Bannock Street, MC 0188, Denver, CO 80204, USA.
出版信息
J Orthop Sci. 2011 Jan;16(1):93-8. doi: 10.1007/s00776-010-0016-0. Epub 2011 Jan 25.
OBJECTIVE
The purpose of this study was to evaluate the effect of Cox-2 administration on direct (primary) fracture healing.
METHODS
A transverse tibial osteotomy was created in adult male rabbits and rigidly fixed in compression using a 2.7-mm dynamic compression plate. Animals were randomized to receive either rofecoxib (12.5 mg orally per day) or placebo. Animals were killed at 4 weeks and fracture healing assessed by mechanical testing.
RESULTS
There were no significant differences between the control and Cox-2 treated animals in terms of mechanical strength at 4 weeks. There was a high complication rate of peri-implant fractures during the daily medication administration.
CONCLUSION
The immediate administration of a Cox-2 specific inhibitor did not impair primary (direct) bone healing at the dose administered in this rabbit tibial osteotomy model.
目的
本研究旨在评估给予环氧化酶-2（Cox-2）对直接（一期）骨折愈合的影响。
方法
在成年雄性兔中制造胫骨横向截骨术，并使用2.7毫米动力加压钢板进行刚性加压固定。将动物随机分为两组，分别给予罗非昔布（每天口服12.5毫克）或安慰剂。在4周时处死动物，并通过力学测试评估骨折愈合情况。
结果
在4周时，对照组和接受Cox-2治疗的动物在力学强度方面没有显著差异。在每日给药期间，植入物周围骨折的并发症发生率较高。
结论
在本兔胫骨截骨术模型中，按所给剂量立即给予Cox-2特异性抑制剂不会损害一期（直接）骨愈合。
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