Yanagawa H, Sone S, Okubo A, Fukuta K, Nishioka Y, Ogura T
Third Department of Internal Medicine, University of Tokushima School of Medicine.
Jpn J Clin Oncol. 1990 Dec;20(4):356-63.
Interferon-gamma (IFN-gamma) acts on a large array of different types of cell and has potent immunomodulatory activities besides cytotoxic effects on tumors. In a phase I study, some immunologic parameters of blood mononuclear cells from healthy volunteers who received intramuscular injections of natural human IFN-gamma were analyzed. The percentage of Leu-11a positive cells, natural killer (NK) activity, lymphokine (interleukin-2)-activated killer (LAK) activity and monokine production were measured either in blood mononuclear cells or in purified samples of lymphocytes or monocytes of the donors before and 24 h after IFN-gamma injection. After IFN-gamma injection, the percentage of Leu-11a positive cells and the LAK activity in the blood were significantly reduced, but NK activity and monokine production remained unchanged. These findings suggest that in vivo IFN-gamma acts directly or indirectly on Leu-11a positive cells and reduces LAK activity by changing the recruitment of LAK precursors in the blood.
γ干扰素（IFN-γ）作用于大量不同类型的细胞，除了对肿瘤具有细胞毒性作用外，还具有强大的免疫调节活性。在一项I期研究中，分析了接受肌肉注射天然人γ干扰素的健康志愿者血液单核细胞的一些免疫参数。在注射γ干扰素之前和之后24小时，测定供体血液单核细胞或纯化的淋巴细胞或单核细胞样本中的Leu-11a阳性细胞百分比、自然杀伤（NK）活性、淋巴因子（白细胞介素-2）激活的杀伤（LAK）活性和单核因子产生。注射γ干扰素后，血液中Leu-11a阳性细胞百分比和LAK活性显著降低，但NK活性和单核因子产生保持不变。这些发现表明，体内γ干扰素直接或间接作用于Leu-11a阳性细胞，并通过改变血液中LAK前体的募集来降低LAK活性。
