Institut für Pathophysiologie und Allergieforschung, Medizinische Universität Wien, 1090 Wien, Austria.
Biochem Soc Trans. 2011 Jan;39(1):360-4. doi: 10.1042/BST0390360.
Both helminth infections and contact with allergens result in development of a Th2 type of immune response in the affected individual. In this context, the hygiene hypothesis suggests that reduced prevalence of parasitic infections and successful vaccination strategies are causative for an increase of allergies in industrialized countries. It is therefore of interest to study glycans and their role as immunogenic structures in both parasitic infections and allergies. In the present paper we review information on the different types of glycan structure present in proteins from plant and animal food, insect venom and helminth parasites, and their role as diagnostic markers. In addition, the application of these glycan structures as immunomodulators in novel immunotherapeutic strategies is discussed.
寄生虫感染和接触过敏原都会导致受影响个体产生 Th2 型免疫反应。在这种情况下，卫生假说表明寄生虫感染的流行率降低和成功的疫苗接种策略是导致工业化国家过敏增加的原因。因此，研究聚糖及其作为寄生虫感染和过敏的免疫原性结构的作用很有意义。在本文中，我们综述了来自植物和动物食物、昆虫毒液和寄生虫的蛋白质中存在的不同类型聚糖结构及其作为诊断标志物的作用的信息。此外，还讨论了这些聚糖结构作为新型免疫治疗策略中的免疫调节剂的应用。
