Katz R J
Division of Cardiology, George Washington University Medical Center, Washington, DC 20037.
Cardiovasc Drugs Ther. 1990 Feb;4(1):247-52. doi: 10.1007/BF01857640.
With the increased use of long-acting nitroglycerin preparations, there has been greater recognition of the problem of nitrate tolerance. In recent years extensive research has broadened our understanding of the mechanisms of nitroglycerin action and the mechanisms of drug attenuation. This paper reviews the current state of knowledge regarding nitroglycerin tolerance, with an emphasis on the concepts of cellular and neurohumoral mechanisms of drug attenuation. The discussion includes potential approaches to prevent nitrate tolerance, including the introduction of a nitrate-free interval, or concomitant administration of sulfhydryl donors or neurohumoral blocking agents.
随着长效硝酸甘油制剂使用的增加，人们对硝酸盐耐受性问题有了更深入的认识。近年来，广泛的研究拓宽了我们对硝酸甘油作用机制和药物衰减机制的理解。本文综述了关于硝酸甘油耐受性的当前知识状态，重点关注药物衰减的细胞和神经体液机制的概念。讨论内容包括预防硝酸盐耐受性的潜在方法，包括引入无硝酸盐间隔期，或同时给予巯基供体或神经体液阻断剂。
