Department of Health Professions, School of Health, Psychology and Social Care, Manchester Metropolitan University, Elizabeth Gaskell Campus, Hathersage Road, Manchester, M13 0JA, UK.
Rheumatol Int. 2012 May;32(5):1277-84. doi: 10.1007/s00296-010-1729-2. Epub 2011 Jan 26.
Hypermobility syndrome (HMS) is a major source of morbidity in children. Impaired quality of life (QoL) has been observed recently in adults with HMS; however, this issue is yet to be investigated in children with this condition. This study compared pain intensity and QoL in children with HMS with healthy controls. It also examined the relationship between pain intensity and QoL in children with HMS. Following ethical approval, 29 children diagnosed with HMS and 37 healthy children aged 8-15 years participated. Informed written consent was obtained from participants and their parents/guardians. Average knee pain over the past week was examined using the Coloured Analogue Scale. QoL was measured via the Pediatric Quality of Life Inventory. Mann-Whitney U tests were performed to compare pain and QoL scores between the two groups. Spearman Rho correlation analysis was performed to examine the relationship between pain and QoL. Overall QoL scores in each domain were significantly lower in children with HMS (all p < 0.001) compared with the controls. Pain intensity was significantly higher in children with HMS compared with their healthy counterparts (p < 0.001). A strong negative correlation was observed between pain intensity and overall QoL and all the domains (r range = -0.614 to -0.717; all p < 0.001). In conclusion, the findings of the present study imply that pain and QoL assessment might form important components of clinical examination for children diagnosed with HMS. These children may benefit from appropriate treatment programmes to alleviate pain intensity and improve QoL.
纤维肌痛综合征（HMS）是儿童发病的主要原因。最近发现 HMS 成年人的生活质量（QoL）受损；然而，这个问题尚未在患有这种疾病的儿童中进行调查。本研究比较了 HMS 患儿与健康对照组的疼痛强度和生活质量。还检查了 HMS 患儿疼痛强度与生活质量之间的关系。在获得伦理批准后，29 名被诊断患有 HMS 的儿童和 37 名年龄在 8-15 岁的健康儿童参加了该研究。从参与者及其父母/监护人那里获得了知情书面同意。使用彩色模拟量表检查过去一周的平均膝关节疼痛。使用儿科生活质量量表测量生活质量。 Mann-Whitney U 检验用于比较两组之间的疼痛和生活质量评分。Spearman Rho 相关分析用于检查疼痛和生活质量之间的关系。与对照组相比，患有 HMS 的儿童的整体生活质量评分在每个领域都明显较低（均 p < 0.001）。与健康对照组相比，患有 HMS 的儿童的疼痛强度明显更高（p < 0.001）。观察到疼痛强度与整体生活质量和所有领域之间存在强烈的负相关（r 范围=-0.614 至-0.717；均 p < 0.001）。总之，本研究的结果表明，疼痛和生活质量评估可能成为 HMS 患儿临床检查的重要组成部分。这些儿童可能受益于适当的治疗方案，以减轻疼痛强度并提高生活质量。
