Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, St George's Hospital Medical School, London, UK.
Prenat Diagn. 2011 Feb;31(2):186-95. doi: 10.1002/pd.2677. Epub 2011 Jan 4.
The aim of this study is to outline the aetiology and outcome of a series of fetuses with non-immune hydrops (NIH), detected prenatally. The findings are compared with a comprehensive review of recent reports.
This is a retrospective study reviewing all pregnancies complicated by NIH in the fetus and continued after 20 weeks of pregnancy over a period of 10 years. Outcome was obtained from postmortem reports, discharge summaries, communication with the clinicians or information from the parents. A literature search was also performed to identify all reports on NIH in the last 10 years.
Seventy-one fetuses affected by NIH were included in this study. The aetiology of the NIH was identified prenatally in 40 cases. The most common causes of NIH were thoracic disorders, infections and cardiovascular disorders. Forty-four of the 71 (62%) fetuses were live-born. There were 10 neonatal deaths. Of the remaining 34 babies, 17 infants survived without morbidity.
The survival rate of NIH is at least 48% in this study. Prenatal identification of the cause is possible in 56% of cases. The risk of neurodevelopmental delay in those that survive is 3 of 28 (11%).
本研究旨在概述一系列经产前检测出的非免疫性胎儿水肿（NIH）的病因和结局。研究结果与最近的综合文献回顾进行了比较。
这是一项回顾性研究，回顾了 10 年来在妊娠 20 周后继续妊娠并伴有 NIH 的所有妊娠。结局通过尸检报告、出院小结、与临床医生的沟通或家长提供的信息获得。还进行了文献检索，以确定过去 10 年中所有关于 NIH 的报告。
本研究纳入了 71 例 NIH 胎儿。40 例 NIH 胎儿的病因在产前得到了明确。NIH 最常见的病因是胸内疾病、感染和心血管疾病。71 例胎儿中有 44 例为活产。有 10 例新生儿死亡。在其余 34 名婴儿中，17 名婴儿存活且无并发症。
本研究中 NIH 的存活率至少为 48%。56%的病例可以在产前确定病因。存活者中出现神经发育迟缓的风险为 3/28（11%）。
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