Sugai Shunya, Haino Kazufumi, Hayashi Masako, Nirei Jun, Yoshihara Kosuke, Nishijima Koji
Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, Niigata, JPN.
Pediatrics, Niigata University Medical and Dental Hospital, Niigata, JPN.
Cureus. 2024 Jun 17;16(6):e62552. doi: 10.7759/cureus.62552. eCollection 2024 Jun.
This report aims to investigate the association between 47,XXX and fetal hydrops by examining a clinical case and performing a comprehensive review of the relevant literature. A 34-year-old Japanese woman, gravida 2, para 1, was diagnosed with fetal hydrops at 27 weeks' gestation. Prenatal testing revealed a 47,XXX karyotype. Interventions included thoracocentesis and a thoracoamniotic shunt. A cesarean delivery was performed at 34 weeks and the female neonate initially had respiratory challenges. After 69 days in the neonatal intensive care unit, the infant was discharged in stable condition, and the 47,XXX karyotype was confirmed. This case may add evidence suggesting an association between 47,XXX and fetal hydrops. Chromosomal abnormalities are causes of fetal hydrops, but its association with 47,XXX remains unclear. Providing comprehensive information on this condition to couples is crucial, and considering the inclusion of fetal hydrops in the list of associated conditions might be advisable.
本报告旨在通过研究一个临床病例并全面回顾相关文献，探讨47,XXX与胎儿水肿之间的关联。一名34岁的日本女性，孕2产1，在妊娠27周时被诊断为胎儿水肿。产前检查显示其核型为47,XXX。干预措施包括胸腔穿刺术和胸腔羊膜分流术。孕34周时进行了剖宫产，女婴出生后最初出现呼吸问题。在新生儿重症监护病房住院69天后，婴儿病情稳定出院，47,XXX核型得到确认。该病例可能为47,XXX与胎儿水肿之间的关联提供证据。染色体异常是胎儿水肿的病因，但其与47,XXX的关联仍不明确。向夫妇提供关于这种情况的全面信息至关重要，考虑将胎儿水肿列入相关病症清单可能是明智的。
