Translational Research Center, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan.
J Cell Biochem. 2011 Feb;112(2):409-14. doi: 10.1002/jcb.22971.
Runt-related (Runx) transcriptional regulators play essential roles in various cell fate determination processes, and dysfunction of these regulators causes many human diseases. Considerable insight into the functions of Runx proteins was provided mainly by studies of hematopoietic and skeletal disorders. Recently, extensive investigations have revealed new functions of these transcription factors in immune cell differentiation and functioning. In the present review, we discuss the mechanisms of selective IgA production in the intestine and report the involvement of Runx proteins in this process.
Runt 相关（Runx）转录因子在各种细胞命运决定过程中发挥着重要作用，这些调节剂的功能障碍会导致许多人类疾病。对 Runx 蛋白功能的深入了解主要来自对造血和骨骼疾病的研究。最近，大量研究揭示了这些转录因子在免疫细胞分化和功能中的新功能。在本综述中，我们讨论了肠道中选择性 IgA 产生的机制，并报告了 Runx 蛋白在这一过程中的参与。
