Nishat T A
Department of Pharmacology, Rawalpindi Medical College.
J Pak Med Assoc. 1990 Nov;40(11):263-6.
Effects of verapamil and cimetidine were studied on smooth muscle of rat stomach by using an isolated fundus strip preparation. Verapamil 0.5 microgram/ml significantly (P less than 0.001) reduced acetylcholine (Ach) induced contractions of rat stomach fundus strip. The inhibition was very prolong and dose dependent. On the other hand cimetidine 60 micrograms/ml significantly (P less than 0.001) potentiated the Ach-induced contractions, potentiation was dose related. The spontaneous contractions of stomach strip were completely abolished by 8 micrograms/ml verapamil, whereas 1000 micrograms/ml cimetidine had no effect. It was concluded that verapamil given for cardiovascular disorders would also supplement relief of pain from peptic ulcer and might prevent stress ulcer formation.
采用离体胃底肌条制备法，研究了维拉帕米和西咪替丁对大鼠胃平滑肌的作用。0.5微克/毫升的维拉帕米显著（P<0.001）降低了乙酰胆碱（Ach）诱导的大鼠胃底肌条收缩。这种抑制作用非常持久且呈剂量依赖性。另一方面，60微克/毫升的西咪替丁显著（P<0.001）增强了Ach诱导的收缩，增强作用与剂量相关。8微克/毫升的维拉帕米可完全消除胃肌条的自发收缩，而1000微克/毫升的西咪替丁则无此作用。得出的结论是，用于治疗心血管疾病的维拉帕米也可能有助于缓解消化性溃疡的疼痛，并可能预防应激性溃疡的形成。
