Apinantriyo Benjawan, Lekhakula Arnuparp, Rujirojindakul Pairaya
Department of Medicine, Faculty of Medicine, Prince of Songkla University, Kanchanavanich Road, Hat Yai, Thailand.
Hematology. 2011 Jan;16(1):50-3. doi: 10.1179/102453311X12902908411715.
Agranulocytosis is a rare but fatal condition. The majority of cases are associated with drugs. However, in-patient incidences and the relationship between clinical outcomes and bone marrow characteristics have not been established.
We conducted a retrospective study in a university hospital. A total of 38 in-patients diagnosed with agranulocytosis were analyzed.
The average incidence of agranulocytosis in Songklanagarind Hospital between 1993 and 2007 was 0·98 cases per 10 000 admissions per year. Antimicrobial agents were the most common etiology (63% of patients) and antithyroid agents were the second most common (13·6%). Two patterns of bone marrow were noted: type I was characterized by a left-shifted granulopoiesis and type II was recognized as having hypocellular bone marrow with markedly reduced granulocyte precursors. A significantly higher mortality was associated with type II.
Antimicrobial agents are the most common cause and the rare granulocyte precursors in bone marrow are associated with higher mortality rates.
粒细胞缺乏症是一种罕见但致命的疾病。大多数病例与药物有关。然而，住院发病率以及临床结局与骨髓特征之间的关系尚未明确。
我们在一家大学医院进行了一项回顾性研究。共分析了38例诊断为粒细胞缺乏症的住院患者。
1993年至2007年期间，宋卡王子大学医院粒细胞缺乏症的平均发病率为每年每10000例入院患者中有0.98例。抗菌药物是最常见的病因（63%的患者），抗甲状腺药物是第二常见的病因（13.6%）。观察到两种骨髓模式：I型的特征是粒细胞生成左移，II型被认为是骨髓细胞减少且粒细胞前体明显减少。II型的死亡率显著更高。
抗菌药物是最常见的病因，骨髓中罕见的粒细胞前体与更高的死亡率相关。
