Department of Internal Medicine and Public Health, University of Bari, Bari, Italy.
Clin Exp Rheumatol. 2011 Jan-Feb;29(1):93-5. Epub 2011 Feb 23.
Rheumatoid arthritis is associated with an increased risk of adverse pregnancy outcomes. TNF inhibitors are effective in the treatment of signs and symptoms of the disease although their safety during pregnancy is debated.
Two cases of women with rheumatoid arthritis in complete remission of the disease with etanercept who decided to continue the therapy throughout their pregnancy are presented. A longitudinal evaluation of the disease activity showed a satisfactory control and good pregnancy outcomes were obtained. A flare of the disease after delivery was not observed.
Etanercept seems to be safe during pregnancy and lactation. A good control of the activity of the disease was reported throughout the pregnancy and during puerperium, when a reactivation of rheumatoid arthritis is often observed.
类风湿关节炎与不良妊娠结局的风险增加有关。TNF 抑制剂可有效治疗疾病的体征和症状，但在妊娠期的安全性存在争议。
本文介绍了两例患有类风湿关节炎的女性患者，她们在使用依那西普治疗后疾病完全缓解，并决定在整个孕期继续接受治疗。疾病活动的纵向评估显示控制情况令人满意，且获得了良好的妊娠结局。分娩后未观察到疾病复发。
依那西普在妊娠期和哺乳期似乎是安全的。据报道，整个孕期和产褥期疾病活动均得到良好控制，而此时类风湿关节炎常出现复发。
