National Neurology Institute, 29 street e/t D and E, Vedado, Plaza, Havana City, Cuba.
Seizure. 2011 May;20(4):280-4. doi: 10.1016/j.seizure.2010.12.010. Epub 2011 Jan 26.
To determine whether antiepileptic drugs constitute in themselves an independent risk factor for suicidality in patients with epilepsy.
One hundred and thirty one patients with epilepsy were recruited and followed-up during 5 years. A detailed medical history, neurological examination, EEGs, Mini-International Neuropsychiatric Interview, executive function, and MRI were assessed. Systematically collected data were used to assess suicidality. Multiple regression analysis was carried out to examine predictive associations between clinical variables, psychiatric disorders, antiepileptic drugs and suicidality.
We identified two AEDs related with suicide attempts (PHB and LTG) and four with suicidal risk: PHB, PRM, PHT and LTG, but the increased of risk diminished or disappeared when psychiatric comorbidity and other well established risk factors for suicidality were analyzed. We found a significant proportion of patients with depressive episodes associated with Topiramate, Phenitoin, Phenobarbital and Lamotrigine.
Antiepileptic drugs probably do not have an impact on suicidality.
确定抗癫痫药物本身是否是癫痫患者自杀的一个独立危险因素。
招募了 131 名癫痫患者，并在 5 年内进行了随访。对患者进行了详细的病史、神经系统检查、脑电图、Mini-国际神经精神访谈、执行功能和 MRI 评估。系统收集的数据用于评估自杀倾向。采用多元回归分析，考察临床变量、精神障碍、抗癫痫药物与自杀倾向之间的预测关系。
我们发现两种 AED 与自杀企图有关（PHB 和 LTG），四种与自杀风险有关：PHB、PRM、PHT 和 LTG，但当分析精神共病和其他自杀的既定危险因素时，风险增加减少或消失了。我们发现，相当一部分患有抑郁发作的患者与托吡酯、苯妥英钠、苯巴比妥和拉莫三嗪有关。
抗癫痫药物可能不会对自杀倾向产生影响。
