度洛西汀治疗伴发抑郁的 2 型糖尿病患者性功能障碍的改善。
Improvement in sexual functioning in patients with type 2 diabetes and depression treated with bupropion.
机构信息
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA.
出版信息
Diabetes Care. 2011 Feb;34(2):332-4. doi: 10.2337/dc10-1714.
OBJECTIVE
Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied.
RESEARCH DESIGN AND METHODS
This article reports a planned secondary analysis of SF in 90 patients with type 2 diabetes treated with BU for MDD.
RESULTS
At baseline, 71.1% of patients had insufficient SF. Mean Sexual Energy Scale (SES) scores improved during treatment (P < 0.0001), as did the percentage with sufficient SF (30.6 vs. 68.1%, P = 0.001). Patients with persistent hyperglycemia had higher rates of sexual dysfunction; however, SES improvement was evident in some with persistent depression or hyperglycemia (18.2% and 25.9%, respectively).
CONCLUSIONS
Insufficient SF is prevalent and may be suspected in patients with MDD and type 2 diabetes. BU treatment of MDD had few sexual side effects and was associated with significant improvements in SF.
目的
重度抑郁症（MDD）和 2 型糖尿病对性功能（SF）均有独立的不良影响。据报道，安非他酮（BU）的副作用较少，但尚未研究其在糖尿病中的应用。
研究设计和方法
本文报告了对 90 例 MDD 用 BU 治疗的 2 型糖尿病患者的 SF 进行的一项计划的二次分析。
结果
基线时，71.1%的患者 SF 不足。治疗期间，性精力量表（SES）评分改善（P<0.0001），SF 充足的患者比例也增加（30.6%比 68.1%，P=0.001）。持续高血糖的患者性功能障碍发生率更高；然而，一些持续抑郁或高血糖的患者 SES 改善明显（分别为 18.2%和 25.9%）。
结论
MDD 和 2 型糖尿病患者中 SF 不足较为常见，应予以怀疑。BU 治疗 MDD 的副作用较少，与 SF 的显著改善相关。
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