Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA.
Diabetes Care. 2011 Feb;34(2):332-4. doi: 10.2337/dc10-1714.
Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied.
This article reports a planned secondary analysis of SF in 90 patients with type 2 diabetes treated with BU for MDD.
At baseline, 71.1% of patients had insufficient SF. Mean Sexual Energy Scale (SES) scores improved during treatment (P < 0.0001), as did the percentage with sufficient SF (30.6 vs. 68.1%, P = 0.001). Patients with persistent hyperglycemia had higher rates of sexual dysfunction; however, SES improvement was evident in some with persistent depression or hyperglycemia (18.2% and 25.9%, respectively).
Insufficient SF is prevalent and may be suspected in patients with MDD and type 2 diabetes. BU treatment of MDD had few sexual side effects and was associated with significant improvements in SF.
重度抑郁症（MDD）和 2 型糖尿病对性功能（SF）均有独立的不良影响。据报道，安非他酮（BU）的副作用较少，但尚未研究其在糖尿病中的应用。
本文报告了对 90 例 MDD 用 BU 治疗的 2 型糖尿病患者的 SF 进行的一项计划的二次分析。
基线时，71.1%的患者 SF 不足。治疗期间，性精力量表（SES）评分改善（P<0.0001），SF 充足的患者比例也增加（30.6%比 68.1%，P=0.001）。持续高血糖的患者性功能障碍发生率更高；然而，一些持续抑郁或高血糖的患者 SES 改善明显（分别为 18.2%和 25.9%）。
MDD 和 2 型糖尿病患者中 SF 不足较为常见，应予以怀疑。BU 治疗 MDD 的副作用较少，与 SF 的显著改善相关。
