It never rains but it pours: potential role of butyrophilins in inhibiting anti-tumor immune responses.
作者信息
Cubillos-Ruiz Juan R, Conejo-Garcia Jose R
出版信息
Cell Cycle. 2011 Feb 1;10(3):368-9. doi: 10.4161/cc.10.3.14565.
Abstract
摘要
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It never rains but it pours: potential role of butyrophilins in inhibiting anti-tumor immune responses.祸不单行：嗜乳脂蛋白在抑制抗肿瘤免疫反应中的潜在作用
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A common 56-kilobase deletion in a primate-specific segmental duplication creates a novel butyrophilin-like protein.一个在灵长类动物特异性片段重复序列中常见的 56 千碱基缺失导致了一个新的但类似于粘蛋白的蛋白。
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BTN3A2 expression in epithelial ovarian cancer is associated with higher tumor infiltrating T cells and a better prognosis.BTN3A2 在卵巢上皮性癌中的表达与肿瘤浸润 T 细胞增多及预后较好相关。
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本文引用的文献
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CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.CD277是一种由卵巢癌微环境细胞普遍表达的负性共刺激分子。
Oncotarget. 2010 Sep;1(5):329-38. doi: 10.18632/oncotarget.165.
2
A butyrophilin family member critically inhibits T cell activation.一个丁酰膦蛋白家族成员可显著抑制 T 细胞激活。
J Immunol. 2010 Nov 15;185(10):5907-14. doi: 10.4049/jimmunol.1000835. Epub 2010 Oct 13.
3
Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity.刺激人源丁酸亲和蛋白 3 分子可导致细胞免疫负调控。
J Leukoc Biol. 2010 Oct;88(4):757-67. doi: 10.1189/jlb.0309156. Epub 2010 Jul 7.
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BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.BTN1A1，乳腺丁酰膦蛋白，和 BTN2A2 都是 T 细胞激活的抑制剂。
J Immunol. 2010 Apr 1;184(7):3514-25. doi: 10.4049/jimmunol.0900416. Epub 2010 Mar 5.
5
Inhibitory B7-family molecules in the tumour microenvironment.肿瘤微环境中的抑制性B7家族分子。
Nat Rev Immunol. 2008 Jun;8(6):467-77. doi: 10.1038/nri2326.
6
BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory molecule modulated in intestinal inflammation.BTNL2是一种嗜乳脂蛋白/B7样分子，是一种在肠道炎症中受到调节的负性共刺激分子。
J Immunol. 2007 Feb 1;178(3):1523-33. doi: 10.4049/jimmunol.178.3.1523.
7
BTNL2, a butyrophilin-like molecule that functions to inhibit T cell activation.BTNL2，一种具有抑制T细胞活化功能的类嗜乳脂蛋白分子。
J Immunol. 2006 Jun 15;176(12):7354-60. doi: 10.4049/jimmunol.176.12.7354.
8
Sarcoidosis is associated with a truncating splice site mutation in BTNL2.结节病与BTNL2基因中的一个截短剪接位点突变有关。
Nat Genet. 2005 Apr;37(4):357-64. doi: 10.1038/ng1519. Epub 2005 Feb 27.
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Frontline: Characterization of BT3 molecules belonging to the B7 family expressed on immune cells.前沿：免疫细胞上表达的属于B7家族的BT3分子的特征
Eur J Immunol. 2004 Aug;34(8):2089-99. doi: 10.1002/eji.200425227.
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