双时相 18F-FDG PET/CT 对偶然发现的甲状腺结节的诊断和预测价值有限。
Limited diagnostic and predictive values of dual-time-point 18F FDG PET/CT for differentiation of incidentally detected thyroid nodules.
机构信息
Department of Nuclear Medicine, School of Medicine, Pusan National University, Busan, 602-739, Republic of Korea.
出版信息
Ann Nucl Med. 2011 Jun;25(5):347-53. doi: 10.1007/s12149-011-0468-0. Epub 2011 Jan 27.
OBJECTIVE
To assess usefulness of dual-time-point (18)F FDG PET/CT to differentiate malignant from benign thyroid nodules and predict the potential factor for malignancy.
METHODS
Fifty patients (age 38-83 years, mean 58 ± 10.6 years) with thyroid nodule were recruited. The (18)F FDG PET/CT images were analyzed visually and quantitatively.
RESULTS
The optimal visual grade of early and delayed images was >grade 3. When SUV(max1) of >2.9 was used as cut off point, the sensitivity and specificity were 55.5 and 63.4%. When SUV(max2) was >3.1, the sensitivity and specificity were 88.8 and 43.9%. When %ΔSUV(max) was ≤9.09%, the sensitivity and specificity were 33.3 and 87.8%. ROC analyses showed that all indices had similar efficacy without significances. No definite predictor could be found for malignant nodules.
CONCLUSION
The dual-time-point (18)F FDG PET/CT is not a useful method for differentiating malignant and benign nodules.
目的
评估双时相（18）F-FDG PET/CT 区分甲状腺良恶性结节及预测恶性潜在因素的作用。
方法
招募 50 名甲状腺结节患者（年龄 38-83 岁，平均 58±10.6 岁）。对（18）F-FDG PET/CT 图像进行视觉和定量分析。
结果
早期和延迟图像的最佳视觉分级>3 级。当 SUV(max1)＞2.9 作为截断值时，敏感性和特异性分别为 55.5%和 63.4%。当 SUV(max2)＞3.1 时，敏感性和特异性分别为 88.8%和 43.9%。当 %ΔSUV(max)≤9.09%时，敏感性和特异性分别为 33.3%和 87.8%。ROC 分析表明，所有指标的效果相似，无统计学意义。未发现恶性结节的明确预测因子。
结论
双时相（18）F-FDG PET/CT 不是区分良恶性结节的有效方法。
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