Takeda Y, Kuroda M, Suzuki A
Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan.
Acta Pathol Jpn. 1990 Oct;40(10):780-4. doi: 10.1111/j.1440-1827.1990.tb01544.x.
A large ameloblastoma with prominent stromal ossification is reported. The patient was a 39-year-old Japanese male with diffuse swelling of the mandible from the left molar to the right premolar region. Radiographic examination showed a radiopaque lesion suggestive of a fibro-osseous lesion. However, histologic examination revealed the lesion to be a variant of follicular ameloblastoma. Most of the tumor cells appeared to be squamous metaplasia. The stroma was abundant, with prominent formation of bone trabeculae rimmed by osteoblasts. Differentiation of mesenchymal cells into active osteoblasts with formation of new bone trabeculae was frequently found in the stroma. The prominent stromal bone formation appeared to be reactive in nature, although it remains uncertain whether this type of ameloblastoma can be regarded as a discrete clinicopathologic entity.
报告了一例伴有显著间质骨化的大型成釉细胞瘤。患者为一名39岁的日本男性，下颌骨从左侧磨牙至右侧前磨牙区域弥漫性肿胀。影像学检查显示一个不透X线的病变，提示为骨纤维性病变。然而，组织学检查显示该病变为滤泡型成釉细胞瘤的一种变体。大多数肿瘤细胞似乎发生了鳞状化生。间质丰富，有成骨细胞包绕的明显骨小梁形成。在间质中经常发现间充质细胞分化为活跃的成骨细胞并形成新的骨小梁。尽管这种类型的成釉细胞瘤是否可被视为一个独立的临床病理实体仍不确定，但显著的间质骨形成似乎本质上是反应性的。
