原发性进展型多发性硬化症（PPMS）患者的胸腺输出减少和外周初始 CD4 T 细胞改变。
Reduced thymic output and peripheral naïve CD4 T-cell alterations in primary progressive multiple sclerosis (PPMS).
机构信息
Department of Pathology, McGill University, 3775 rue University, Montreal, QC, Canada H3A 2B4.
出版信息
J Neuroimmunol. 2011 Apr;233(1-2):233-9. doi: 10.1016/j.jneuroim.2010.12.007. Epub 2011 Jan 26.
We compared naïve CD4 and CD8 T-cell homeostasis in primary progressive multiple sclerosis (PPMS), relapsing-remitting MS (RRMS) and controls. Quantitation of signal joint T-cell receptor (TCR) excision circles (sjTRECs) and quantitative estimates of daily thymic export confirm our previous report of reduced thymic output in RRMS and demonstrate reduced thymic output in PPMS. In PPMS, the decreasing % CD31+ naïve CD4 T-cells but constant sjTRECs and constant naïve CD4 T-cell numbers with age, together with increased Bcl-2 expression suggest increased TCR signaling with increased naïve T-cell survival. We conclude PPMS patients have peripheral immune alterations related to reduced thymic output.
我们比较了原发性进展型多发性硬化症（PPMS）、复发缓解型多发性硬化症（RRMS）和对照组中幼稚 CD4 和 CD8 T 细胞的固有平衡。信号接头 T 细胞受体（TCR）切除环（sjTRECs）的定量和每日胸腺输出的定量估计证实了我们之前关于 RRMS 中胸腺输出减少的报告，并证明了 PPMS 中胸腺输出减少。在 PPMS 中，随着年龄的增长，%CD31+幼稚 CD4 T 细胞减少，但 sjTRECs 和幼稚 CD4 T 细胞数量保持不变，同时 Bcl-2 表达增加，这表明 TCR 信号增加伴随着幼稚 T 细胞存活增加。我们得出结论，PPMS 患者存在与胸腺输出减少相关的外周免疫改变。
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