Zimon I N, Mavlianova N A, Khoroshaev V A, Karimov E A
Khirurgiia (Mosk). 1990 Nov(11):43-9.
The article deals with the analysis of the course of the disease, the postoperative period, and complications in 293 patients and the results of study of the red cell ultrastructure and the acid-base equilibrium and blood gas composition in 33 patients with thrombosis and embolism of the main limb arteries. It was shown that the blood, its red cells, is the system which is mainly affected by endotoxins and high concentrations of biologically active substances occurring in the blood flow. According to the form of the red cells (normocytes, echinocytes, spheroechinocytes) and the quantitative relationship the depth of the pathological process can be judged. Shifts of the acid-base equilibrium in the direction of metabolic acidosis is compensated by intensified lung ventilation. Metabolic alkalosis appears in advanced cases. The revealed shift should be taken into account in applying intensive therapy.
本文分析了293例患者的疾病病程、术后情况及并发症，以及33例主肢体动脉血栓形成和栓塞患者的红细胞超微结构、酸碱平衡和血气成分的研究结果。结果表明，血液及其红细胞是主要受内毒素和血流中高浓度生物活性物质影响的系统。根据红细胞的形态（正常红细胞、棘红细胞、球形棘红细胞）及数量关系可判断病理过程的深度。代谢性酸中毒方向的酸碱平衡改变可通过加强肺通气得到代偿。晚期病例会出现代谢性碱中毒。在应用强化治疗时应考虑到所揭示的这种变化。
