1,3-苯二甲酰基二硫代脲的高效合成与生物评价。
Efficient synthesis and biological evaluation of 1,3-benzenedicarbonyl dithioureas.
机构信息
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, and College of Chemistry, Central China Normal University, Wuhan 430079, PR China.
出版信息
Bioorg Med Chem Lett. 2011 Feb 15;21(4):1102-4. doi: 10.1016/j.bmcl.2010.12.130. Epub 2011 Jan 1.
PMID:21273072
Abstract
The synthesis and biological activity of 1,3-benzenedicarbonyl dithioureas are described. Bioassay results indicated that these compounds exhibited cytotoxicity against various cancer cells. For example, compounds 4a showed the best inhibition activities against KB and CNE2 with IC(50) 10.72 and 9.91 μM, respectively.
摘要
本文描述了 1,3-苯二甲酰基二硫代脲的合成及生物活性。生物测定结果表明，这些化合物对多种癌细胞具有细胞毒性。例如，化合物 4a 对 KB 和 CNE2 的抑制活性最好，IC（50）分别为 10.72 和 9.91 μM。
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