Laboratory for Advanced Research in Natural and Synthetic Chemistry, V. G. Vaze College, Mumbai University, Mithagar road, Mumbai, India.
Chem Biodivers. 2011 May;8(5):841-9. doi: 10.1002/cbdv.201000116.
New retinobenzoic acid derivatives have been synthesized starting from 1,2,3,4-tetrahydro-1,1,2,4,4,6-hexamethylnaphthalene and 1,1,2,3,3-pentamethylindane. Four of the synthetic compounds displayed potent cytotoxic activities in vitro against human breast cancer and leukemic cell lines. Thus, these molecules can be further evaluated for the treatment of human leukemia and breast cancer.
新型的雷托苯并酸衍生物已经通过 1,2,3,4-四氢-1,1,2,4,4,6-六甲基萘和 1,1,2,3,3-五甲基茚满为起始原料合成。四种合成化合物在体外对人乳腺癌和白血病细胞系显示出很强的细胞毒性活性。因此，这些分子可以进一步评估用于治疗人类白血病和乳腺癌。
