Department of Neuroscience, Columbia University, New York, NY 10032, USA.
J Neurophysiol. 2011 May;105(5):1963-5. doi: 10.1152/jn.01104.2010. Epub 2011 Jan 27.
Juvenile animal brains are highly plastic and thus often achieve better functional recovery after injury compared with adult brains. Recently, Umeda et al. (Umeda T, Takahashi M, Isa K, Isa T. J Neurophysiol 104: 1707-1716, 2010) have shown that the remodeling of both corticospinal and extra-pyramidal pathways can contribute to the recovery of grasping and reaching ability in hemidecorticated juvenile rats. They have further unveiled the strengthening of the cortico-reticulo-spinal pathway after injury, that mediates the fast excitation of ipsilateral motoneurons for functional recovery.
幼年动物的大脑具有高度的可塑性，因此在受伤后往往比成年动物的大脑能更好地恢复功能。最近，Umeda 等人（Umeda T，Takahashi M，Isa K，Isa T. J Neurophysiol 104: 1707-1716, 2010）表明，皮质脊髓和皮质下通路的重塑有助于半脑切除的幼年大鼠抓握和伸展能力的恢复。他们进一步揭示了损伤后皮质网状脊髓通路的增强，该通路介导了同侧运动神经元的快速兴奋，从而促进了功能恢复。
