双歧杆菌乳亚种可减轻结肠炎小鼠模型的炎症发作。
Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis.
机构信息
Department of Nutrition and Health, Nestlé Research Centre, Vers-chez-les-Blanc, Lausanne 26, Switzerland.
出版信息
World J Gastroenterol. 2011 Jan 28;17(4):459-69. doi: 10.3748/wjg.v17.i4.459.
Abstract
AIM
To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis.
METHODS
Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice.
RESULTS
All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis.
CONCLUSION
Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis.
摘要
目的
在结肠炎的过继转移模型中评估益生菌双歧杆菌（B. lactis）的抗炎作用。
方法
供体和受体小鼠在转移幼稚和调节性 T 细胞混合物之前一周通过饮用水接受 B. lactis 或对照（德氏乳杆菌培养基），直到处死。
结果
所有受体小鼠均出现结肠炎症迹象，但与对照组相比，B. lactis 喂养的受体小鼠体重减轻明显减少。此外，发现黏膜厚度变薄和上皮损伤减轻的趋势。与对照组相比，B. lactis 喂养的受体小鼠结肠中促炎和 T 细胞标志物的表达明显降低。同时，B. lactis 显著上调叉头框蛋白 3，一种调节性 T 细胞的标志物。
结论
在结肠炎的小鼠模型中，每日口服 B. lactis 能够减少炎症和 T 细胞介质，并促进调节性 T 细胞特异性标志物的表达。
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