Diaz Keith M, Feairheller Deborah L, Sturgeon Kathleen M, Veerabhadrappa Praveen, Williamson Sheara T, Crabbe Deborah L, Brown Michael D
Hypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, College of Health Professions, Temple University, Philadelphia, PA 19122, USA.
Int J Hypertens. 2011 Jan 9;2010:137206. doi: 10.4061/2010/137206.
We investigated the relationship between renal function, blood pressure variability (BPV), and nitric oxide (NO) in a group of African Americans with normal or mildly impaired renal function. 24-hour ambulatory blood pressure monitoring was performed, NO measured, and glomerular filtration rate (GFR) calculated in 38 African Americans. Participants were categorized as having normal (GFR > 90 mL/min per 1.73 m(2)) or mildly impaired (GFR 60-89 mL/min per 1.73 m(2)) renal function. Diastolic BPV was significantly lower in the mildly impaired renal function group. Regression analyses revealed a significant positive association between GFR and diastolic BPV for the entire study group. Plasma NO levels were significantly higher in the mildly impaired renal function group and negatively correlated with diastolic BPV. In conclusion, diastolic BPV was reduced in African Americans with mildly impaired renal function, which may be the result of increased NO production. These results conflict with previous findings in diseased and nonblack populations and could provide rationale for studying BPV early in the disease state when BP-buffering mechanisms are still preserved.
我们在一组肾功能正常或轻度受损的非裔美国人中，研究了肾功能、血压变异性（BPV）和一氧化氮（NO）之间的关系。对38名非裔美国人进行了24小时动态血压监测，测量了NO，并计算了肾小球滤过率（GFR）。参与者被分为肾功能正常（GFR>90 mL/分钟/1.73 m²）或轻度受损（GFR 60 - 89 mL/分钟/1.73 m²）两组。轻度肾功能受损组的舒张压变异性显著较低。回归分析显示，整个研究组中GFR与舒张压变异性之间存在显著正相关。轻度肾功能受损组的血浆NO水平显著较高，且与舒张压变异性呈负相关。总之，肾功能轻度受损的非裔美国人的舒张压变异性降低，这可能是NO生成增加的结果。这些结果与之前在患病和非黑人人群中的研究结果相矛盾，并且可以为在疾病状态早期，当血压缓冲机制仍然存在时研究血压变异性提供理论依据。
