Röther J
Neurologische Abteilung, Asklepios Klinik Altona, Hamburg, Deutschland.
Nervenarzt. 2011 Feb;82(2):159-60, 162-5. doi: 10.1007/s00115-010-3111-8.
Atrial fibrillation (AF) is the most common cardiac arrhythmia, affects approximately 1% of adults and prevalence increases with age. Nine per cent of those aged 80 years and older have AF. AF is associated with increased cardiovascular mortality and morbidity, including stroke.Stroke in patients with AF is more severe and more likely to be fatal. Prevention of thromboembolism with oral anticoagulants and rate or rhythm control are the main therapeutic strategies for patients with AF. Vitamin K antagonists reduce the risk of stroke in patients with AF, however are underutilized. Dronedarone is the first antiarrhythmic drug that reduces the stroke rate.
心房颤动(AF)是最常见的心律失常,影响约1%的成年人,且患病率随年龄增长而增加。80岁及以上人群中有9%患有AF。AF与心血管疾病死亡率和发病率增加相关,包括中风。AF患者发生的中风更严重,且更有可能致命。使用口服抗凝剂预防血栓栓塞以及控制心率或心律是AF患者的主要治疗策略。维生素K拮抗剂可降低AF患者中风风险,但未得到充分利用。决奈达隆是第一种可降低中风发生率的抗心律失常药物。