Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University, CA 94305-5406, USA.
Curr Cardiol Rep. 2011 Apr;13(2):138-44. doi: 10.1007/s11886-011-0168-3.
Conventional algorithms and noninvasive imaging tests for the identification of stable, hemodynamically significant coronary artery disease offer little insight into the detection of potentially vulnerable and inflamed coronary plaques, those most likely to rupture and cause acute coronary syndromes. Positron emission tomography (PET) with fluorodeoxyglucose (FDG) serves as a potential novel modality for the identification of plaque inflammation, as initial studies in animal and human studies have demonstrated that FDG uptake correlates with macrophage accumulation and inflammation. Therapy with anti-inflammatory agents has also been demonstrated in the arterial vasculature to reduce plaque FDG uptake. Although imaging of coronary inflammation with FDG-PET holds tremendous promise, several hurdles remain to be surmounted prior to widespread clinical application.
传统的算法和无创影像学检查方法可用于识别稳定的、血流动力学意义明确的冠状动脉疾病，但对于检测潜在易损和炎症的冠状动脉斑块却没有太多的了解，而这些斑块最有可能破裂并导致急性冠状动脉综合征。正电子发射断层扫描（PET）结合氟脱氧葡萄糖（FDG）可作为一种潜在的新型斑块炎症识别方法，因为动物和人体研究的初步研究表明，FDG 摄取与巨噬细胞积聚和炎症相关。在动脉血管中使用抗炎药物治疗也已被证明可以减少斑块 FDG 摄取。虽然 FDG-PET 对冠状动脉炎症的成像具有巨大的应用潜力，但在广泛应用于临床之前，仍有几个障碍需要克服。
