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在流动反应器内部使用磁性材料进行感应加热。

Inductive heating with magnetic materials inside flow reactors.

机构信息

Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany.

出版信息

Chemistry. 2011 Feb 7;17(6):1884-93. doi: 10.1002/chem.201002291. Epub 2011 Jan 7.

Abstract

Superparamagnetic nanoparticles coated with silica gel or alternatively steel beads are new fixed-bed materials for flow reactors that efficiently heat reaction mixtures in an inductive field under flow conditions. The scope and limitations of these novel heating materials are investigated in comparison with conventional and microwave heating. The results suggest that inductive heating can be compared to microwave heating with respect to rate acceleration. It is also demonstrated that a very large diversity of different reactions can be performed under flow conditions by using inductively heated flow reactors. These include transfer hydrogenations, heterocyclic condensations, pericyclic reactions, organometallic reactions, multicomponent reactions, reductive cyclizations, homogeneous and heterogeneous transition-metal catalysis. Silica-coated iron oxide nanoparticles are stable under many chemical conditions and the silica shell could be utilized for further functionalization with Pd nanoparticles, rendering catalytically active heatable iron oxide particles.

摘要

硅胶或钢珠涂层超顺磁纳米粒子是新型的固定床材料,可用于在感应场下在流动条件下有效加热反应混合物的流动反应器。与传统和微波加热相比,研究了这些新型加热材料的范围和局限性。结果表明,感应加热可以与微波加热在加速速率方面进行比较。还证明了可以通过使用感应加热的流动反应器在流动条件下进行非常多样化的不同反应。这些包括转移氢化、杂环缩合、周环反应、有机金属反应、多组分反应、还原环化、均相和多相过渡金属催化。在许多化学条件下,氧化硅涂层的氧化铁纳米粒子是稳定的,并且可以利用二氧化硅壳进一步功能化钯纳米粒子,得到催化活性的可加热氧化铁颗粒。

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